We have identified a novel pathway in bone that is important for skeletal development and bone turnover and which involves thyroid hormone regulation of the fibroblast growth factor / heparan sulphate / fibroblast growth factor receptor signalling complex. The aims of the research project are to determine how T3 regulates expression and activity of FGFRs and heparan sulphate proteoglycans (HSPGs) and to investigate the hypothesis that T3 regulates FGFR signalling by modification of HSPG structure.
HD Bassett and GR. Williams (2003) The molecular actions of thyroid hormone in bone. Trends in Endocrinology and Metabolism (In Press)
JHD Bassett, P Rashbass, B Harding, SA Forbes, AAJ Pannett and RV Thakker (1999). Studies of the murine homologue of the multiple Endocrine neoplasia type 1 (MEN1) gene, men1. Journal of Bone and Mineral Research 14: 3-10
JHD Bassett, SA Forbes, AAJ Pannett, SE Lloyd, PT Christie, C Wooding, B Harding, GM Besser, CR Edwards, JP Monson, J Sampson, JAH Wass, MH Wheeler and RV Thakker (1998). Characterisation of mutations in patients with multiple Endocrine neoplasia type 1 (MEN1). American Journal of Human Genetics 62: 232-244
JHD Bassett, SA Forbes, AAJ Pannett and RV Thakker (within the European Consortium on MEN1) (1997). Identification of the multiple Endocrine neoplasia type 1 (MEN1) gene. Human Molecular Genetics6: 1177-1183